Matthew T. Cook

Assistant Professor

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Education

• Ph.D. Biomedical Sciences; University of Missouri – Columbia (2015)
• M.S. Biology ; University of Central Missouri (2010)
• B.S. Cell and Molecular Biology – Missouri State University (2007)

Courses Taught

• Allied Physiology
• Human Physiology

Academic Interests

Identifying conceptual ideas that do not align to the scientifically validated phenomenon.  For students to succeed these preconceptions, alternative conceptions and/or misconceptions in physiology need to be addressed.  One of these misaligned concepts has the potential to compound the learning difficulties as the concepts build.

Current Research Interests

• Investigating the preventative and chemotherapeutic potential of the natural low-toxic flavonoid luteolin in progestin-dependent models of breast cancer.
• Characterizing and identifying the potent anti-metastatic properties of luteolin in triple negative breast cancer.

Scholarly Activity

• Liang, Y., Besch-Williford, C., Cook, M. T., Belenchia, A., Brekken, R. A., & Hyder, S. M. (2019). APR-246 alone and in combination with a phosphatidylserine-targeting antibody inhibits lung metastasis of human triple-negative breast cancer cells in nude mice. Breast Cancer: Targets and Therapy, 11, 249.  PMID: 31534364.
• Cook, M. T. (2018). Mechanism of metastasis suppression by luteolin in breast cancer. Breast Cancer: Targets and Therapy, 10, 89. PMID: 29928143.
• Cook, M. T., Liang, Y., Besch-Williford, C. L., and Hyder, S. (2017). Luteolin inhibits the metastatic potential of triple-negative breast cancer cells in vivo. Breast Cancer: Targets and Therapy, 23:9, 9-19. PMID: 28096694.
• Goyette, S., Liang, Y., Mafuvadze, B., Cook, M. T., Munir, M., and Hyder, S. M. (2017). Natural and Synthetic Progestins Enrich Cancer Stem Cell-like Cells in Hormone- Responsive
• Human Breast Cancer Cell Populations In Vitro. Breast Cancer: Targets and Therapy, 2017:9, 1-11. PMID: 28579829.
• Cook, M. T., Mafuvadze, B., Besch-Williford, C. L., Ellersieck M. R., Goyette, S., & Hyder, S. (2016). "Luteolin suppresses development of medroxyprogesterone acetate-accelerated 7, 12-dimethylbenz (a) anthracene-induced mammary tumors in Sprague-Dawley rats." Oncology Reports, 35(2), 825-832. PMID: 26719029.
• Cook, M. T., Liang, Y., Goyette, S., Mafuvadze, B., Besch-Williford, C., & Hyder, S. (2015).
• Luteolin inhibits progestin-dependent angiogenesis, stem cell-like characteristics, and growth of human breast cancer xenografts. Springerplus, 4(1), 444. PMID: 26312209.
• Liang, Y., Besch-Williford, C., Aebi, J. D., Mafuvadze, B., Cook, M. T., Zou, X., & Hyder, S. M. (2014). Cholesterol biosynthesis inhibitors as potent novel anti-cancer agents: suppression of hormone-dependent breast cancer by the oxidosqualene cyclase inhibitor RO 48-8071. Breast Cancer Research and Treatment, 146, 51-62. PMID: 24878988.
• Mafuvadze, B., Cook, M., Xu, Z., Besch-Williford, C. L., & Hyder, S. M. (2013). Effects of Dietary Apigenin on Tumor Latency, Incidence and Multiplicity in a Medroxyprogesterone Acetate-Accelerated 7, 12-Dimethylbenz(a)anthracene-Induced Breast Cancer Model.
• Nutrition and Cancer, 65, 1184-1191. PMID: 24127693.
• Lui, J., Walker, N.M., Cook, M.T., Ootani, A., and Clarke, L.L. (2011). Functional Cftr in Crypt Epithelium of Organotypic Enteroid Cultures from Murine Small Intestine. American Journal of Physiology-Cell Physiology, 302, C1492-C1503. PMID: 22403785.

Student Group Advisement

Pre-Health Occupations Club (PHOC) Faculty Advisor

Other Professional Experiences

• Member of American Association for Cancer Research                                                     
• Member of Center for the Integration of Research, Teaching and Learning                         
• Member of Golden Key International Honour Society