2010 Schedule (12-2, 9-0 MIAA)
| Date | Opponent | Location | Time/Result | Additional Info |
| Sept. 2 | Texas A&M-Kingsville | Bearcat Stadium | L, 7-16 | Recap - Photos |
| Sept. 18 | Nebraska-Omaha* | Omaha, Neb. | W, 58-23 | Recap - Photos |
| Sept. 25 | Truman* | Kirksville, Mo. | W, 44-10 | Recap - Photos |
| Oct. 2 | Missouri Western* (Family Weekend) |
Bearcat Stadium | W, 42-0 | Recap - Photos |
| Oct. 9 | Missouri Southern* | Joplin, Mo. | W, 49-21 | Recap - Photos |
| Oct. 16 | Emporia State* | Bearcat Stadium | W, 42-28 | Recap - Photos |
| Oct. 23 | Washburn* | Topeka, Kan. | W, 41-40 | Recap |
| Oct. 30 | Fort Hays State* (Homecoming) |
Bearcat Stadium | W, 45-27 | Recap - Photos |
| Nov. 6 | Central Missouri* | Warrensburg, Mo. | W, 17-16 | Recap - Photos |
| Nov. 13 | vs. Pittsburg State* (Fall Classic IX at Arrowhead) |
Kansas City, Mo. | W, 22-16 | Recap - Photos |
| Nov. 20 | NCAA Playoffs - First Round #6 Missouri Western at #3 Northwest |
Bearcat Stadium | W, 28-24 | Recap - Photos |
| Nov. 27 | NCAA Playoffs - Second Round #3 Northwest at #2 Texas A&M-Kingsville |
Kingsville, Texas | W, 35-31 | Recap - Photos |
| Dec. 4 | NCAA Playoffs - Quarterfinals #4 Central Missouri at #3 Northwest |
Bearcat Stadium | W, 37-20 | Recap - Photos |
| Dec. 11 | NCAA Playoffs - Semifinals Northwest at Minnesota Duluth |
Duluth, Minn. | L, 13-17 | Recap |
*=MIAA Competition
Home games in GREEN played in Maryville, Mo.
