After World War II, Northwest changed its name from Northwest Missouri State Teachers College to Northwest Missouri State College. The new name reflected the change that Northwest was undergoing in its student population. Northwest was training as many business professionals as it was educators.
During the State College years, the school would undergo tremendous growth with new buildings such as the Olive DeLuce Fine Arts Building (1964), new majors and larger enrollment. The school would also mourn the loss of one of its students in an on-campus tragedy and welcome such distinguished visitors as President Harry S. Truman and Eleanor Roosevelt.