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Ph.D. - Pharmaceutical Chemistry, University of Kansas - Lawrence, KS
Preparation and Analytical Characterization of Nanosuspensions for Poorly Water Soluble Pharmaceuticals
The utilization of high-throughput combinatorial screening methods in pharmaceutical discovery has resulted in the identification of drug molecules of very high potency and selectivity for potentially therapeutically relevant receptors. Unfortunately, the optimization of these biological properties are often obtained at the expense of other physical chemical properties of the compound, such as aqueous solubility, which are required for successful development of a formulation with acceptable in-vivo performance. Formulation and analytical challenges in Pharmaceutical Research and Development are extensive for these compounds. One option to address the delivery of poorly water soluble drugs is to reduce the particle size below the 1 mm level to obtain nanoparticles. Dr. Riley’s research interests are in the area of preparation of nanosuspension formulations of pharmaceutically active compounds with a focus on analytical characterization.
Although nanosuspensions may be prepared relatively easily, the challenge in formulation development is to identify a formulation that will be chemically and physically stable without any particle size growth over the shelf-life of a product. Currently optimization of nanosuspension formulations is a trial and error method performed by adding various stabilizers to formulations and determining the long term stability of formulations using analytical methods such as particle size analysis and microscopy techniques. Dr. Riley’s research untilizes analytical methods such as particle size analysis, zeta potential analysis, scanning electron microscopy and atomic force microscopy to evaluate intermolecular interactions (steric and electrostatic in nature) in nanosuspensions to help aid in the selection of stabilizers that would be predicted to result in stable formulations. Additional characterization techniques including x-ray powder diffraction, thermal analysis, and HPLC are routinely used to obtain a thorough understanding of the physical and chemical properties of nanosized drug substance within the formulations.