This website is best viewed in a browser that supports web standards.

Skip to content or, if you would rather, Skip to navigation.

Northwest Missouri State University

Dr. Shelley Riley

Dr. Shelley Riley

Assistant Professor

Ph.D. - Pharmaceutical Chemistry, University of Kansas - Lawrence, KS

Area of Expertise

  • Analytical Chemistry
  • Fourteen years of pharmaceutical industry experience in preformulation and formulation development. (Experience in physical chemical characterization, polymorphic screening/physical form selection, stability studies, drug delivery, formulation development for preclinical and clinical studies.)

Expanded Bio » View PDF

Publications and Patents

  • Eighteen publications in peer-reviewed journals
  • Three patents
  • Murphy, D. and Rabel, S. (2008)  Thermal Analysis and Calorimetric Methods for Characterization of New Crystalline Forms.  In:  Preformulation in Solid Dosage Form Development;  Adeyeye, C., Brittain, H., Eds.; Informa Healthcare USA, Inc.; New York, NY, 279 – 322.
  • Riley, C.M.; Rabel Riley, S.R.; Phelps, R.L.  (2014) Assay and Impurities.  In Specification of Drug Substance and Products: Development and Validation of Analytical Methods;  Riley, C.M., Rosanske, T.W., Rabel, Riley S.R., Eds.;  Elsevier: Oxford, UK, 109-142.  
  • Riley, S.R. (2014).  “An Integrated Approach to Thermal Analysis of Pharmaceutical Solids”, Journal of Chemical Education, ASAP Online Publication 11-20-14.

Research Interests

Preparation and Analytical Characterization of Nanosuspensions for Poorly Water Soluble Pharmaceuticals

The utilization of high-throughput combinatorial screening methods in pharmaceutical discovery has resulted in the identification of drug molecules of very high potency and selectivity for potentially therapeutically relevant receptors.  Unfortunately, the optimization of these biological properties are often obtained at the expense of other physical chemical properties of the compound, such as aqueous solubility, which are required for successful development of a formulation with acceptable in-vivo performance.  Formulation and analytical challenges in Pharmaceutical Research and Development are extensive for these compounds.  One option to address the delivery of poorly water soluble drugs is to reduce the particle size below the 1 mm level to obtain nanoparticles.   Dr. Riley’s research interests are in the area of preparation of nanosuspension formulations of pharmaceutically active compounds with a focus on analytical characterization. 

Although nanosuspensions may be prepared relatively easily, the challenge in formulation development is to identify a formulation that will be chemically and physically stable without any particle size growth over the shelf-life of a product.  Currently optimization of nanosuspension formulations is a trial and error method performed by adding various stabilizers to formulations and determining the long term stability of formulations using analytical methods such as particle size analysis and microscopy techniques.  Dr. Riley’s research untilizes analytical methods such as particle size analysis, zeta potential analysis, scanning electron microscopy and atomic force microscopy to evaluate intermolecular interactions (steric and electrostatic in nature) in nanosuspensions to help aid in the selection of stabilizers that would be predicted to result in stable formulations.  Additional characterization techniques including x-ray powder diffraction, thermal analysis, and HPLC are routinely used to obtain a thorough understanding of the physical and chemical properties of nanosized drug substance within the formulations.